Camptothecins in Cancer Therapy
Val R. Adams
A critical review our current understanding of camptothecins, their shortcomings, and of the possibilities for improving their clinical performance. The authors discuss new camptothecin analog development, drug delivery issues for optimizing their anticancer activity, and their potential use in a variety of different cancers. Additional chapters describe what is known about the biochemistry, the pharmacology, and the chemistry of the camptothecins, including the mechanism of topoisomerase and how camptothecins poison this enzyme, the use of animal models in defining the anticancer potential of camptothecins, and the question of camptothecin resistance.
Kategorije:
Godina:
2005
Izdanje:
1
Izdavač:
Humana Press
Jezik:
english
Strane:
474
ISBN 10:
1588290271
ISBN 13:
9781588290274
Serije:
Cancer Drug Discovery and Development
Fajl:
PDF, 7.17 MB
IPFS:
,
english, 2005
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